The Biological
Precision Clock
Epigenetic clocks represent the golden standard of human aging measurement. By analyzing 850,000+ methylation sites, we can determine your bodies true cellular age with unrivaled accuracy.
What Is Biological Age?
Biological age estimates how old your body is at the cellular and molecular level, independent of your birth date. Two 50-year-olds can have dramatically different biological ages based on genetics, lifestyle, diet, and environment.
The most validated approach uses epigenetic clocks — algorithms that analyze DNA methylation patterns at specific sites across your genome. These patterns change predictably with age, and deviations from expected patterns indicate accelerated or decelerated aging.
Key epigenetic clocks include Horvath (the original pan-tissue clock), GrimAge (best predictor of mortality), and DunedinPACE (measures your current rate of aging rather than cumulative age). A comprehensive test like TruDiagnostic reports all of these.
Testing Providers
We've evaluated the leading consumer biological age tests for scientific rigor, comprehensiveness, and value.
Tally Health
SinclairEpigenetic (DNA Methylation)
$229/test or $149/test with subscription
Founded by David Sinclair, Tally Health uses a cheek swab to measure DNA methylation patterns and calculate your biological age. Includes a daily supplement and personalized action plan.
Methodology
Uses a proprietary epigenetic clock based on DNA methylation analysis. Measures ~900 CpG sites. Results include a TallyAge score and rate-of-aging metric.
TruDiagnostic (TruAge)
Epigenetic (DNA Methylation)
$229 (COMPLETE) / $499 (COMPLETE+)
The most comprehensive consumer epigenetic test. TruAge COMPLETE measures biological age using multiple epigenetic clocks including DunedinPACE (rate of aging), immune cell composition, and telomere length estimation.
Methodology
Uses the Illumina EPIC array to measure 900,000+ CpG sites. Reports multiple validated clocks: Horvath, Hannum, PhenoAge, GrimAge, and DunedinPACE. The most scientifically rigorous consumer option.
GlycanAge
Glycan-based
$295/test
GlycanAge measures your biological age through IgG glycosylation patterns — the sugar molecules attached to your antibodies. This reflects immune system aging and chronic inflammation levels.
Methodology
Analyzes glycan patterns on IgG antibodies from a dried blood spot. Glycan profiles shift with age and are responsive to lifestyle interventions (often within 3–6 months), making them good for tracking changes.
InsideTracker
SinclairBlood Biomarker Panel
$249–$899 depending on panel
Blood biomarker platform that measures up to 43 blood markers and calculates an InnerAge score. Sinclair is an advisor. Provides personalized nutrition, exercise, and supplement recommendations.
Methodology
Uses a standard blood draw to measure markers like glucose, hsCRP, ApoB, testosterone, cortisol, and more. The InnerAge algorithm weights these markers against population data to estimate biological age.
A Note on Biological Age Testing
Epigenetic clocks are powerful research tools, but consumer tests have limitations. Test-retest variability can be 1–3 years, meaning small changes between tests may be noise. Different clocks can give different results for the same person.
Use biological age as a directional signal, not a precise measurement. Track trends over 6–12 months rather than obsessing over a single number. And remember: the interventions with the largest effect on biological age are free — exercise, sleep, stress management, and diet quality.