Essentials

NMN is a direct precursor to NAD+, a coenzyme critical for energy metabolism, DNA repair, and sirtuin activation. NAD+ levels decline significantly with age, and restoring them is a central thesis of modern longevity science.

Omega-3 fatty acids — particularly EPA and DHA — are among the most well-studied supplements for aging. They reduce systemic inflammation, support cardiovascular health, and have been linked to longer telomeres.

Vitamin D deficiency accelerates multiple aging biomarkers. D3 supplementation is one of the most broadly supported interventions, especially for those over 40 or living in northern latitudes. K2 ensures calcium goes to bones, not arteries.

Creatine is one of the most studied supplements in history. Beyond athletic performance, it supports muscle preservation in aging, cognitive function, and directly participates in cellular ATP recycling — making it relevant to the mitochondrial energy thesis of aging.

CoQ10 is a critical component of the mitochondrial electron transport chain, directly involved in ATP production. Levels decline with age and with statin use. Ubiquinol is the reduced (active) form with better bioavailability.

Magnesium is involved in over 300 enzymatic reactions and most adults are deficient. Glycinate form is gentle and well-absorbed; threonate (Magtein) crosses the blood-brain barrier for cognitive support.

Hydrolyzed collagen peptides provide amino acids (glycine, proline, hydroxyproline) that serve as building blocks for skin, cartilage, and connective tissue. Collagen production declines ~1% per year after age 25.

High-quality EVOO is rich in oleocanthal, hydroxytyrosol, and oleuropein — polyphenols with powerful anti-inflammatory and antioxidant effects. The PREDIMED trial established olive oil as one of the most evidence-backed dietary interventions for aging.

Green tea catechins — particularly EGCG (epigallocatechin gallate) — are among the most studied plant compounds for health and longevity. Populations with high green tea consumption consistently show lower rates of cardiovascular disease and certain cancers.

Photobiomodulation uses specific wavelengths of red (630–670nm) and near-infrared (810–850nm) light to stimulate mitochondrial function. It's the best-evidenced device category for anti-aging, with applications in skin rejuvenation, wound healing, and inflammation reduction.