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Understand the science behind anti-aging interventions. We explain the mechanisms, cite the studies, and flag where the evidence is strong, emerging, or overhyped.
Why We Age: The Hallmarks of Aging
An overview of the 12 hallmarks of aging — from genomic instability to stem cell exhaustion — and which ones are targetable with current interventions.
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NAD+ and Sirtuins: The Sinclair Thesis
David Sinclair's information theory of aging posits that aging is caused by loss of epigenetic information, and NAD+-dependent sirtuins are the repair mechanism. What does the evidence actually support?
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Mitochondria, ATP, and the Energy Theory of Aging
How mitochondrial dysfunction drives aging, the role of membrane potential in ATP production, and what you can actually do about it (spoiler: exercise is #1).
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Epigenetic Clocks: Measuring Biological Age
From Horvath to DunedinPACE — how DNA methylation clocks work, what they measure, their limitations, and how to interpret your results.
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Bioelectric Medicine: Levin, Voltage, and Regeneration
Michael Levin's groundbreaking research on bioelectric signaling, what it means for aging, and why consumer 'cell voltage' products aren't the same thing.
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Senolytics: Clearing Zombie Cells
Senescent cells accumulate with age and poison their neighbors. Senolytic drugs like dasatinib+quercetin and fisetin aim to clear them. Where does the evidence stand?
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Photobiomodulation: How Red Light Affects Mitochondria
The mechanism behind red/near-infrared light therapy — cytochrome c oxidase, nitric oxide dissociation, and downstream ATP effects. Plus: how to evaluate devices.
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The Supplement Industry: Reading Labels and Spotting Hype
Third-party testing, bioavailability, proprietary blends, and the difference between 'clinically studied ingredients' and actual clinical evidence for a product.
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